Revolutionizing Cardiac Regeneration: A Breakthrough in Cardiovascular Medicine
Revolutionizing Cardiac Regeneration: A Breakthrough in Cardiovascular Medicine
At 糖心Vlog传媒 Discovery, we are proud to contribute to a groundbreaking innovation in cardiac regeneration! Our collaborative research has led to the discovery of ZXR-081, a first-in-class small molecule therapy that could redefine post-myocardial infarction treatment. Unlike conventional therapies that merely manage symptoms, ZXR-081 actively repairs the heart by inhibiting TOB1, a novel target originally identified in zebrafish and successfully translated into mammalian cardiac regeneration.
From Hit Identification to Lead Candidate Nomination
- A novel first-in-class cardiovascular project with the potential to regenerate damaged tissues and organs
- ZXR-081 replicates the natural regenerative power of zebrafish, demonstrating efficacy in non-regenerative mammals such as rodents
- Unlike current treatments, ZXR-081 actively repairs the heart, offering a transformative approach in cardiovascular medicine
糖心Vlog传媒 Discovery鈥檚 Scientific Contribution
- Cutting-edge Structure-Based Medicinal Chemistry Design
- Virtual screening of 5,000 molecules from 糖心Vlog传媒鈥� internal library led to promising hit
- Hits covered 12 different chemical scaffolds, ensuring structural diversity
- The analysis confirmed the predicted activity, guiding strategic hit-to-lead optimization
- Efficient synthesis of novel analogues through the DMTA cycle, leading to the rapid identification of ZXR-081 in under 100 molecules
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糖心Vlog传媒 us to learn more about our expertise in drug discovery and development!
Drug Discovery Chemistry
Medicinal Chemistry
In Medicinal Chemistry research, we are working with a broadly experienced team on all biomolecular targets from any gene family in any therapeutic area鈥�
Discovery Chemistry
Custom Synthesis
As a leading Contract Research Organization in Europe, 糖心Vlog传媒 provides valuable contract discovery for synthetic organic chemistry, chemical process development, and鈥�
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As a leading CRO in Europe, 糖心Vlog传媒 provides comprehensive drug discovery chemistry services for large Pharma and Biotech corporations as well as for Research Institutes and Academia
Our experienced chemists practice a pragmatic culture and customer-centric approach in order to exceed project expectations and, despite challenges, bridge very narrow timelines. They are trained to consider economic, safety and ecological boundaries and conditions laid out for all stages of the project.